Sources and transports of CO as measured by the Measurement of Air Pollution from Space (MAPS) over a substantial sector of the southern hemisphere between South America and southern Africa are described by air parcel trajectories based upon European Center for Medium Range Weather Forecasts (ECMWF) model data fields. Observations, made by NASA Shuttle astronauts during the October 1994 mission, of vegetation fires suggest a direct relationship between in situ biomass burning, at least over South America and southern Africa, and coincident tropospheric measurements of CO. Results of this paper indicate that the transport of CO from the surface to the levels of maximum MAPS sensitivity (about 450 hPa) over these regions is not of a direct nature due largely to the well stratified atmospheric environment. The atmospheric transport of CO from biomass burning within this region is found to occur over intercontinental scales over numbers of days to more than a week. Three distinct synoptic circulation and transport classes are found to have occurred over southern Africa during the October 1994 MAPS experiment: (1) transport from South America and Africa to southern Africa associated with elevated MAPS measured CO (> 150 ppbv); (2) weakening anticyclonic transport from South America associated with moderate CO (< 150 ppbv and > 105 ppbv); and (3) transport from the high southern latitudes associated with low CO (<105 ppbv).